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The phase 2 study AKCEA-APOCIII-LRx met primary and key secondary endpoints with significant reductions in triglyceride ( TG ) and apoC-III levels, and a favorable safety and tolerability profile in t ...


Results from a prespecified analysis of pooled data from three phase III studies evaluating the safety and efficacy of Inclisiran, a first-in-class investigational treatment for hyperlipidemia in adul ...


The purpose of a study was to evaluate the development in the use of medications associated with an increased risk of developing osteoporosis over the time period from 1999 to 2016. Researchers hav ...


ODYSSEY OLE ( open-label extension ) has included patients diagnosed with heterozygous familial hypercholesterolemia ( HeFH ), receiving maximally tolerated statins, who had completed one of four phas ...


Advanced age is an important risk factor for fracture. The ACTIVE ( Abaloparatide Comparator Trial In Vertebral Endpoints ) trial has shown that subcutaneous Abaloparatide ( Tymlos ) increased bone mi ...


Patients with heterozygous familial hypercholesterolemia ( HeFH ) who completed the double-blind ODYSSEY LONG TERM parent trial and subsequently enrolled in the open-label extension ( OLE ) study, ODY ...


A study aimed to determine whether the concomitant combination therapy of anabolic agents and bisphosphonates produces more effects on bone mineral density ( BMD ) than anabolic agents alone in patien ...


In humans, developing metabolic disease, particularly type 2 diabetes, is correlated with having bacteria that penetrate the mucus lining of the colon. The findings, which provide insight on how pe ...


A new study published today in BMJ Open has found a link between obesity in adolescents and their risk of developing heart disease in early adulthood, regardless of ethnicity. People of South Asian ...


The aim of the present study was to investigate the impact of sleep on osteoporosis. The study used a baseline examination of the Hiroshima Sleep and Healthcare study, which was a cross-sectional a ...


A diet rich in Magnesium may reduce the risk of diseases including heart disease ( heart failure ), stroke and type-2 diabetes mellitus according to a new meta-analysis published in the open access jo ...


The phase 3 GLAGOV ( GLobal Assessment of Plaque ReGression with a PCSK9 AntibOdy as Measured by IntraVascular Ultrasound ) trial evaluating the effect of Evolocumab ( Repatha ) on coronary artery dis ...


Body circumferences have been proposed as potential anthropometric measures for the assessment of cardiometabolic risk as they are independently associated with insulin resistance and diabetes. Th ...


The FDA ( Food and Drug Administration ) has approved the Repatha ( Evolocumab ) Pushtronex system ( on-body infusor with prefilled cartridge ), a new, monthly single-dose administration option. The ...


Evidence is mounting that a diet mimicking the effects of fasting has health benefits beyond weight loss, with a new study indicating that it may reduce symptoms of multiple sclerosis. Researchers di ...