Metabolism Xagena

Xagena Mappa
Medical Meeting

Poor sleep quality may be associated with osteoporosis

The aim of the present study was to investigate the impact of sleep on osteoporosis.

The study used a baseline examination of the Hiroshima Sleep and Healthcare study, which was a cross-sectional and cohort study that addressed the association of sleep habits with lifestyle-related diseases.

A total of 1032 participants ( 25-85 years of age ) who underwent health examinations were included.

Sleep habits, including its timing ( bed time ), quantity ( time in bed [ TIB ] ), and quality, were assessed using the Pittsburgh Sleep Quality Index ( PSQI ).
The bone stiffness index ( SI ), a marker of osteoporosis, was measured using quantitative ultrasound systems.

Bed time ( r = 0.065, p  less than 0.05 ), TIB ( r = -0.064, p  less than 0.05 ), and global PSQI score ( r = -0.126, p  less than 0.0001 ) significantly correlated with SI.

Multiple regression analyses revealed that after adjusting for age, sex, body mass index, smoking, and alcohol intake, the global PSQI score ( β = -0.053, p  less than 0.05 ) was significantly associated with SI, whereas bed time or TIB was not.

Among each component of PSQI, sleep disturbances ( β = -0.084, p  less than 0.005 ) were significantly associated with SI.

In conclusion, poor sleep quality may be associated with osteoporosis. In particular, increased sleep disturbances may be a key factor in the association between poor sleep quality and osteoporosis. ( Xagena )

Sasaki N et al, Sleep Med 2016; 25: 73-77